CHROMABOND® Drug

Octadecyl modified silica phase for SPE, not endcappedBase material silica, pore size 60 Å, particle size 45 µm for C18, specific surface 500 m²/g, pH stability 2 to 8 octadecyl phases, not endcapped, carbon content 14 % possesses more free silanols (SiOH), which allow secondary interactions with polar groups of the analytes.Recommended applications: non-polar compounds, pesticides.

Octadecyl modified silica phase for SPE, endcappedBase material silica, particle size 45 µm for C18 ec, specific surface 500 m²/g, pH stability 2 to 8. Octadecyl phases, endcapped, carbon content 14 % very non-polar, hydrophobic interactions with a wide variety of organic compounds. Advantageous for clean-up of samples with large structural variations (polarity differences).Recommended applications: non-polar compounds, aflatoxins, amphetamines, antibiotics, antiepileptics, barbiturates, caffeine, drugs, preservatives, fatty acids, nicotine, PAHs, pesticides, PCBs, heavy metals, vitamins. Very well suited for desalting of samples.

Octyl modified silica phase for SPE, not endcappedBase material silica, pore size 60Å, particle size 45µm, specific surface 500m²/g, pH stability 2 to 8. Octyl phase, not endcapped, carbon content 8%, similar to C18, however slightly more polar. Secondary interactions with polar compounds are more pronounced due to shorter alkyl chains.Recommended applications: pesticides, PCBs.

Octadecyl modified silica phase for SPE of polar analytesBase material silica, pore size 60 Å, particle size 45 µm, specific surface 500 m²/g, pH stability 2 to 8, special octadecyl phase for polar analytes, not endcapped, carbon content 15 %.Recommended applications: more polar compounds like pesticides and their polar degradation products, phenols, phenoxycarboxylic acids, nitroaromatics, pharmaceuticals.

Polar modified polystyrene-divinylbenzene copolymer with a weak anion exchangerSpecific surface 650 to 700 m²/g, particle size 80µm, pore size 50 Å, pH stability 1 to 14. Due to bifunctional modification much more hydrophilic than conventional polystyrene-divinylbenzene polymers and thus easily wettable with water.Recommended applications: polar herbicides / pesticides from water (acidic, neutral, basic), polar phenols from water, polyaromatic compounds, polychlorinated biphenyls, drug analysis from urine, blood, serum, plasma pharmaceuticals / active ingredients from tablets, creams.Due to the bifunctional modification CHROMABOND® Easy is considerably more hydrophilic than conventional polystyrene-divinylbenzene polymers and thus easily wettable with water. The Easy effect: Aqueous samples can be loaded directly without preconditioning! This means that little or even no conditioning is needed, in contrast to standard SPE materials, where recovery rates normally decrease, in the worst case down to zero! Depending on the separation task conditioning may be required and is recommended for method development. A positive side effect of the excellent wettability: there is no decrease of recovery rates, if the cartridge runs dry, therefore automation is easier or, in some cases compared to silica materials, only feasible with CHROMABOND® Easy, because a permanent vacuum can be used without supervision.Further advantages of using a polymeric material:high surface, this means very high binding capacity (2 - 5 times higher than silica-based adsorbents)less adsorbent is needed in the cartridge (without losing sensitivity or recovery)faster analysis, because the height of the adsorbent bed can be reducedacidic or basic solvents (e. g. TFA) do not destroy the phase, or lead to unintended side productsBecause of the polar modification the material is suitable for a broad range of compounds (acidic, neutral, basic, polar and nonpolar substances). Highly reproducible recovery rates can be obtained, even if the cartridge runs dry (especially advantageous when using 96-well plates, where stopcocks are not available!)

Spherical, hydrophobic polystyrene-divinylbenzene resin for SPEHydrophobic polystyrene-divinylbenzene copolymer pH stability 1 to14. High-purity material with highest reproducibility and lowest blank values due to a novel manufacturing process, spherical particles 85mm; pore size 55 to 60Å. Very high surface 1000m²/g; capacity 390mg/g (caffeine in water). Excellent recovery rates especially for the enrichment of pharmaceuticals/active ingredients due to the spherical structure of the particles, very homogeneous surface, and optimised pore structure.Recommended applications: pharmaceuticals/active ingredients from tablets, creams and water/waste water, drugs and pharmaceuticals from urine, blood, serum and plasma trace analysis of pesticides.Cartridges in further sizes and phases of the HR-X poduct range available on request.

Phenyl modified silica phase for SPEBase material silica, pore size 60Å, particle size 45µm, specific surface 500m²/g, pH stability 2 to 8. Phenyl phase, carbon content 8%polarity similar to C8. In addition to hydrophobic interactions more selective adsorption is possible by Π-Π interactions due to the electron density of the phenyl ring.Recommended applications: aflatoxins, caffeine, phenols.

Aluminium oxide, neutral, pH 7 ±0,5